about hero

CBD 101


In some ways, we are all looking to improve upon the human condition. No matter the reason for turning to a plant still perplexing even the most brilliant minds, an introductory understanding of the cannabinoids becoming ritual for many is essential.

CBD, short for cannabidiol, is one of the most well-known of 100+ different phytochemicals found in the cannabis plant, known as phytocannabinoids. CBD is a sticky resin found concentrated in the trichomes of the hemp plant. Trichomes are glandular structures that protect the plant from heat and ultraviolet radiation. While both marijuana and hemp can contain CBD, Mowellens products are derived from hemp and are non-psychoactive, meaning they will not get you high. This is due to the fact even though hemp and marijuana come from the same genus of Cannabis, the genetic profile of the plants is what makes them unique and different. Hemp contains less than .3% THC while marijuana contains more than .3% THC. THC, short for tetrahydrocannabinol, is the primary psychoactive compound in cannabis.

The Science of CBD in the Human Body

While we are now aware of the body’s endocannabinoid system as a group of endogenous cannabinoid receptors located in the brain, central nervous system, and peripheral nervous system, CBD’s, impact on the body at a molecular level is still being meticulously sorted. This endocannabinoid system is responsible for our homeostasis or the body’s ability to maintain itself and function properly. It is also involved in regulating actions and feelings such as appetite, pain sensation, stress, memory and mood. Receptors in all major organ systems in our body, our brain, stomach, nervous system, and other organs have cellular receptors for the ‘cannabinoids’, and while the primary receptors for phytocannabinoids are CB1 and CB2, CBD works by modulating several non-cannabinoid receptors and ion channels.

Our body also produces two main endogenous cannabinoids or ‘endocannabinoids’, 2AG and Anandamide. These endocannabinoids are part of the endocannabinoid system and are named as such due to their similarity to compounds found in the cannabis plant. As humans are all unique and different, individuals have different congenital endocannabinoid levels and sensitivities. And whether from poor diet, lack of exercise, drug abuse, environmental toxins or genetic factors, endocannabinoid deficits place humans in a position of inability to adapt to chronic stress. This in turn, depletes endocannabinoid tone, causing a domino of physiological responses.

Endocannabinoids are the only neurotransmitters that engage in “retrograde signaling,” a form of intracellular communication that inhibits immune response, reduces inflammation, relaxes musculature, lowers blood pressure, dilates bronchial passages, and normalizes overstimulated nerves. Retrograde signaling serves as an inhibitory feedback mechanism that tells other neurotransmitters to cool it when they are firing too fast.

“Endocannabinoids are central players in life’s multidimensional biochemical balancing act known as homeostasis,” says biologist Robert Melamede, who describes the endocannabinoid system as “the Ur-Regulator,” the master modulator, which is constantly multitasking, adjusting and readjusting the complex network of molecular thermostats that control our physiological tempo.

CBD’s impact, whether delaying reuptake, enhancing or inhibiting helps to regulate our cannabinoid tone and this in return has spawned a revolution in science for the plant providing health and healing around the world.


Your cart is empty. Continue Shopping.